One of my old favorites as far as series go is Slayers, it's a comical fantasy series with serious moments. The first series had some pretty low-budget animation, but Slayers Next really upped the quality. Next also has one of the best endings I've ever seen for a series, hands down. Slayers Try was just kind of "meh", and the animation took a downturn, but it's not bad. The new Slayers series (Revolution and Evolution-R) pick up where they left off and reference a lot of the old stuff; they're really just fanservice for people who liked the old stuff 10 years ago. The novels (yes, novels - it was based on a series of books) are pretty good too, but it's effectively a different continuity. The TV series use a lot of the plot threads from the novels but go in very different directions. Basically start with the concept of several 20th level characters blowing crap up. They start out huge at the beginning and stay that way. English dubs as of the past few years have gotten really good, but I still prefer Slayers in Japanese as that's how I first heard it. I tend to watch a decent amount of recent stuff dubbed, though. My cousin is actually a voice actor in LA, but he hasn't really got much but bit parts in dubs, he prefers doing western animation and video games. If you've played Warriors Orochi or Dynasty Warriors 6, he's Guan Yu; if you're familiar with the webcomic Looking for Group he's Richard in the animated stuff they've put out.